Wratislav “Drslav“ of Mitrowicz († 1487) acquired the homestead Mitrowicz at Sedlčany around 1448 and became a burgrave at the Prague Castle (1462) after an active resistance against Jiří of Poděbrady. Over the 16th century the descendants of the Wratislav´s (Drslav) son Jan Wratislav of Mitrowicz († 1520) divided the dynasty into several lines – of Újezd, Mníšek, Skřipel, the line of Skřipel was divided further.
Václav Wratislav of Mitrowicz (1510 – 1554) was the youngest son of the above-mentioned Jan Wratislav and the growth of the dynasty of Wratislavs started with his ancestors from the marriage with Barbora Vamberská of Rohatec. The growth was besides other things connected with a traditional client relation to the dynasty of masters of Hradec. The Wratislavs faithfully served the masters with the coat of arms with a gold five-leaved rose on a blue field, over 16th century some members of the dynasty of Wratislavs moved to the positions of chief officers at the manor houses of the masters of Hradec, e.g. Vávlav´s son Štěpán held the position of regent at the mansion house of Jindřichov Hradec. His brothers were successful politicians as well – Jiří (a burgrave at the Prague Castle and county representative of the manor house Hluboká), Kryštof (a burgrave at Karlštejn) and Mikuláš (a vice chamberlain of the Kingdom of Bohemia). Štěpáns´ son Václav Ignác Wratislav of Mitrowicz became by far the most important one among them.
In 1591 Václav Ignác Wratislav of Mitrowicz, called "Tureček", got with the bearers of the Emperor Rudolf II to the Turkish sultan in Constantinople (today´s Istanbul) where he was falsely accused of espionage and spent a year and a half in forced labour and two years in the worst Turkish prison, the Black Tower, which was called the grave of the living. After returning from the Turkish prison he wrote down his experiences in the “Příhody Václava Vratislava, svobodného pána z Mitrovic” (The stories of Václav Vratislav, a free master from Mitrovic) which belongs among the most charming renaissance book of travels. He got married to Ludmila Ježová of Luby († 1636) and spent his time in the manor house Starý Knín. Later he participated in the anti-Turkish wars. During the Bohemian Revolt (1618) he supported the Emperor and must have left the Bohemia. After the Battle of White Mountain (1620) he returned back. He became the highest jury of the land, secret Emperor´s advisor and got the aristocratic status in the end.
His grandson, count František Ignác Wratislav of Mitrowicz and Schönfeld (1645-1727) bought the castle in Koloděje nad Lužnicí in 1704.
His son, František Karel I. Wratislav of Mitrowicz, (1696 -1759) with his wife Marie Anna Alžběta Kinská of Vchynice and Tetov (1699-1737) expanded the castle in 1737-1741 and completed the construction of the baroque chapel devoted to Saint Anna. The whole family lived there for a long time.